from Scientific American, January 1998 | by Donald E. Ingber; 10 page(s)



Cover Story: Life's Architecture: cells grow with tensegrity, Scientific American, January 1998; by Donald E. Ingber; 10 page(s)

Life is the ultimate example of complexity at work. An organism, whether it is a bacterium or a baboon, develops through an incredibly complex series of interactions involving a vast number of different components. These components, or subsystems, are themselves made up of smaller molecular components, which independently exhibit their own dynamic behavior, such as the ability to catalyze chemical reactions. Yet when they are combined into some larger functioning unit--such as a cell or tissue--utterly new and unpredictable properties emerge, including the ability to move, to change shape and to grow.

Although researchers have recognized this intriguing fact for some time, most discount it in their quest to explain life's fundamentals. For the past several decades, biologists have attempted to advance our understanding of how the human body works by defining the properties of life's critical materials and molecules, such as DNA, the stuff of genes. Indeed, biologists are now striving to identify every gene in the complete set, known as the genome that every human being carries. Because genes are the "blueprints" for the key molecules of life, such as proteins, this Holy Grail of molecular biology will lead in the near future to a catalogue of essentially all the molecules from which a human is created. Understanding what the parts of a complex machine are made of, however, does little to explain how the whole system works, regardless of whether the complex system is a combustion engine or a cell. In other words, identifying and describing the molecular puzzle pieces will do little if we do not understand the rules for their assembly.

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